徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
TNFSF14 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611006 |
| 100ul | WGD-Z-2611006 |
详细参数
| 别名 | Tumor necrosis factor ligand superfamily member 14; Herpes virus entry mediator ligand; HVEM-L; Herpesvirus entry mediator ligand; CD antigen CD258) [Cleaved into: Tumor necrosis factor ligand superfamily member 14; membrane form; Tumor necrosis factor ligand superfamily member 14; soluble form] |
| 基因名 | TNFSF14 |
| UniProt ID | O43557 |
| 反应种属 | Human |
| 应用 | WB,IHC-P,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 7F9-X7-Q7 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 26 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IHC-1:200; ELISA-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Tumor necrosis factor ligand superfamily member 14 (TNFSF14), also known as LIGHT, is a cytokine that plays a crucial role in immune regulation and inflammation. It functions as a ligand for the TNF receptor superfamily member 14 (TNFRSF14), also known as HVEM, and is involved in T cell activation, proliferation, and cytokine production. TNFSF14 has been shown to promote apoptosis in tumor cells and can inhibit tumor necrosis factor-alpha (TNF-α)-mediated apoptosis in hepatocytes. Dysregulation of TNFSF14 is associated with several diseases, including rheumatoid arthritis and inflammatory bowel disease, where its altered signaling contributes to chronic inflammation. Additionally, elevated levels of TNFSF14 have been linked to certain cancers, such as diffuse large B-cell lymphoma, highlighting its potential role in tumorigenesis. |