徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
PHLPP1 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611029 |
| 100ul | WGD-Z-2611029 |
详细参数
| 别名 | PH domain leucine-rich repeat-containing protein phosphatase 1; Pleckstrin homology domain-containing family E member 1; PH domain-containing family E member 1; Suprachiasmatic nucleus circadian oscillatory protein; hSCOP |
| 基因名 | PHLPP1 |
| UniProt ID | O60346 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 7E7-L7-Y5 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 184 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:500 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | PH domain and leucine rich repeat protein phosphatase 1 (PHLPP1) is a magnesium/manganese-dependent serine/threonine phosphatase that serves as a critical regulator of cell signaling. It specifically dephosphorylates the hydrophobic motif of various AGC kinases, including Akt2/3, PKC alpha/beta, and S6K1, as well as nuclear substrates like STAT1 and histones. By inactivating these targets, PHLPP1 functions as a broad tumor suppressor that dampens the PI3K-Akt and RAS-ERK pathways, thereby limiting cell proliferation and promoting apoptosis. It also modulates metabolic and immune signaling through the repression of receptor tyrosine kinase transcription. Clinically, the loss or dysregulation of PHLPP1 is linked to multiple cancers, including prostate and hematologic malignancies, and is associated with the development of obesity and type 2 diabetes due to impaired insulin signaling. |