徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
TACC2 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611084 |
| 100ul | WGD-Z-2611084 |
详细参数
| 别名 | Transforming acidic coiled-coil-containing protein 2; Anti-Zuai-1; AZU-1 |
| 基因名 | TACC2 |
| UniProt ID | O95359 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 1J3-L1-Z9 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 309 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Transforming acidic coiled-coil-containing protein 2 (TACC2) is a centrosomal protein essential for mitotic spindle organization. It facilitates the coupling of the centrosome to the nucleus and stabilizes microtubules during cell division. TACC2 expression is hormonally responsive, notably to erythropoietin and androgens. In cancer, TACC2 plays a context-dependent role; it is associated with breast and prostate malignancies where it can function as a tumor suppressor or progression marker. Its dysregulation affects cell cycle fidelity and has been linked to specific subtypes like mucinous stomach adenocarcinoma. |