徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
C3 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611113 |
| 100ul | WGD-Z-2611113 |
详细参数
| 别名 | Complement C3; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1) [Cleaved into: Complement C3 beta chain; C3-beta-c; C3bc); Complement C3 alpha chain; C3a anaphylatoxin; Acylation stimulating protein; ASP; C3adesArg); Complement C3b; Complement C3b-alpha' chain); Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2] |
| 基因名 | C3 |
| UniProt ID | P01024 |
| 反应种属 | Human |
| 应用 | WB,IP,CHIP |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2b |
| 克隆号 | 5Z9-V3-K1 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 187 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IP-1:100; CHIP-1:100 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Complement C3 (C3) is a critical protein in the immune system, primarily involved in the complement cascade, which enhances the ability of antibodies and phagocytic cells to clear pathogens. C3 is synthesized mainly in the liver and is the most abundant complement protein in serum. Upon activation, C3 is cleaved into C3a and C3b; C3b acts as an opsonin, marking pathogens for destruction, while C3a promotes inflammation. Deficiencies in C3 can lead to severe immunocompromised states, increasing susceptibility to bacterial infections and autoimmune diseases, such as systemic lupus erythematosus (SLE) and glomerulonephritis. Elevated C3 levels are often seen in inflammatory conditions, including infections and certain malignancies. The dual role of C3 in both promoting immune responses and its involvement in pathological conditions underscores its significance in health and disease. |