徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
ATP1B1 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611145 |
| 100ul | WGD-Z-2611145 |
详细参数
| 别名 | Sodium/potassium-transporting ATPase subunit beta-1; Sodium/potassium-dependent ATPase subunit beta-1 |
| 基因名 | ATP1B1 |
| UniProt ID | P05026 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 4H2-R6-F6 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 35 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:250-1:500 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | ATPase Na+/K+ transporting subunit beta 1 (ATP1B1) encodes the non-catalytic beta-1 glycoprotein subunit of the Na+/K+-ATPase, an essential plasma membrane pump. This enzyme hydrolyzes ATP to maintain the electrochemical gradients of sodium and potassium ions across the cell membrane, which are vital for osmoregulation, nerve excitability, and epithelial polarity. ATP1B1 is responsible for the proper assembly and trafficking of the alpha/beta heterodimer to the plasma membrane. Beyond its role in ion transport, it has been implicated in cell adhesion and the modulation of virus-triggered interferon induction through interactions with TRAF3 and TRAF6. Clinically, polymorphisms in the 3'UTR of the ATP1B1 gene are associated with essential hypertension, likely due to their effects on sodium handling and blood pressure regulation. The protein is ubiquitously expressed, with particularly high levels in the brain, heart, and kidney. |