徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
ABCB1 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611167 |
| 100ul | WGD-Z-2611167 |
详细参数
| 别名 | ATP-dependent translocase ABCB1; ATP-binding cassette sub-family B member 1; Multidrug resistance protein 1; P-glycoprotein 1; Phospholipid transporter ABCB1; CD antigen CD243 |
| 基因名 | P-Glycoprotein |
| UniProt ID | P08183 |
| 反应种属 | Human |
| 应用 | WB,IP,CHIP |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 9R4-X4-I6 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 141 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:2000; IP-1:100; CHIP-1:100 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | ATP binding cassette subfamily B member 1 (P-Glycoprotein) is a 170 kDa transmembrane glycoprotein that functions as an ATP-dependent efflux pump. It is a member of the ABC transporter family and plays a critical role in protecting tissues from toxic xenobiotics by expelling a broad range of substrates from the cytoplasm. P-Glycoprotein is highly expressed in physiological barriers, including the blood-brain barrier, intestines, liver, and kidneys. It operates through an alternating access mechanism, where ATP binding and hydrolysis drive conformational changes between inward-facing and outward-facing states to transport molecules across the membrane. Clinically, P-Glycoprotein is a major factor in multidrug resistance in various cancers, as it actively pumps out chemotherapeutic agents. It also significantly influences the pharmacokinetics and efficacy of drugs used to treat conditions such as epilepsy and HIV. |