徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
PTPN1 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611253 |
| 100ul | WGD-Z-2611253 |
详细参数
| 别名 | Tyrosine-protein phosphatase non-receptor type 1; Protein-tyrosine phosphatase 1B; PTP-1B |
| 基因名 | PTP1B |
| UniProt ID | P18031 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 1H2-Z7-X1 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 49 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:200-1:250 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Protein tyrosine phosphatase non-receptor type 1 (PTP1B) is a ubiquitously expressed cytosolic phosphatase that localizes to the endoplasmic reticulum. It serves as a critical negative regulator of signaling pathways by dephosphorylating phosphotyrosine residues on receptor tyrosine kinases, most notably the insulin and leptin receptors. By attenuating these cascades, PTP1B acts as a metabolic brake, modulating energy homeostasis and cell growth. Functional studies indicate that the inhibition of PTP1B enhances insulin sensitivity and protects against diet-induced obesity. Clinically, PTP1B is a well-established candidate gene for type 2 diabetes and obesity, making it a significant target for therapeutic intervention in metabolic disorders. |