徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
PEBP1 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611326 |
| 100ul | WGD-Z-2611326 |
详细参数
| 别名 | Phosphatidylethanolamine-binding protein 1; PEBP-1; HCNPpp; Neuropolypeptide h3; Prostatic-binding protein; Raf kinase inhibitor protein; RKIP) [Cleaved into: Hippocampal cholinergic neurostimulating peptide; HCNP] |
| 基因名 | RKIP |
| UniProt ID | P30086 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 1V3-C1-C2 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 21 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Phosphatidylethanolamine binding protein 1 (RKIP) is a multifunctional protein that serves as a critical modulator of the MAPK/ERK and NF-kappaB signaling pathways. It functions through a phosphorylation-dependent molecular switch: in its unphosphorylated state, RKIP binds to Raf-1, preventing the activation of MEK and downstream ERK signaling. Upon phosphorylation by protein kinase C at Ser153, RKIP dissociates from Raf-1 and instead inhibits G protein-coupled receptor kinase 2 (GRK2), thereby enhancing GPCR signaling. RKIP also interacts with kinases such as TAK1 and NIK to regulate NF-kappaB activity. Clinically, RKIP is a well-established metastasis suppressor that is frequently downregulated in various cancers, including melanoma and prostate cancer. Its loss promotes tumor progression, invasion, and chemoresistance, and is also linked to inflammatory pathologies such as arthritis. |