徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
SNCA Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611358 |
| 100ul | WGD-Z-2611358 |
详细参数
| 别名 | Alpha-synuclein; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP |
| 基因名 | alpha Synuclein |
| UniProt ID | P37840 |
| 反应种属 | Human |
| 应用 | IHC-P,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 1I9-A5-R9 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 14 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:1000; ELISA-1:250-1:500 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | The SNCA gene provides instructions for making the alpha-synuclein protein, which is abundant in the brain and plays an important role in normal brain function. Alpha-synuclein is found mainly at the tips of nerve cells in specialized structures called presynaptic terminals, where it helps regulate the release of chemical messengers called neurotransmitters. Genetic variations in the SNCA gene have been linked to several neurodegenerative disorders, including Parkinson's disease, Lewy body dementia, and multiple system atrophy. Certain mutations in SNCA can lead to the abnormal accumulation and aggregation of alpha-synuclein protein, which is a hallmark of these diseases. The overproduction of alpha-synuclein due to SNCA gene duplications or triplications has also been associated with autosomal dominant forms of Parkinson's disease. Overall, the SNCA gene and its product alpha-synuclein are considered central to the pathogenesis of various neurodegenerative disorders. |