徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
CAPG Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611362 |
| 100ul | WGD-Z-2611362 |
详细参数
| 别名 | Macrophage-capping protein; Actin regulatory protein CAP-G |
| 基因名 | Actin Regulatory Protein CAPG |
| UniProt ID | P40121 |
| 反应种属 | Human |
| 应用 | WB,IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 2P8-X4-N7 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 38 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IHC-1:500 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Capping actin protein, gelsolin like (Actin Regulatory Protein CAPG) is a calcium-sensitive member of the gelsolin family that regulates actin filament dynamics in non-muscle cells, particularly macrophages. It functions by reversibly capping the barbed ends of F-actin filaments in a manner regulated by calcium and phosphoinositides, thereby controlling actin-based motility without severing existing filaments. CAPG is involved in maintaining cell shape, endocytosis, and the regulation of cytoplasmic and nuclear structures through its interactions with DNA and the cytoskeleton. Clinically, CAPG is overexpressed in several malignancies, including gastric and breast cancers, where it promotes tumor cell invasion and metastasis through extensive actin remodeling. It is also implicated in the progression of fibrosis by enhancing cellular motility. |