徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
MZT1 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611521 |
| 100ul | WGD-Z-2611521 |
详细参数
| 别名 | Mitotic-spindle organizing protein 1; Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1 |
| 基因名 | MZT1 |
| UniProt ID | Q08AG7 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 6Q2-E9-U4 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 8 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:2000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Mitotic spindle organizing protein 1 (MZT1) is a critical component of the centrosome that facilitates the localization of the gamma-tubulin ring complex, which is essential for microtubule nucleation and mitotic spindle organization. It localizes to centrosomes and spindles throughout the cell cycle, playing a key role in the recruitment of signaling molecules and the regulation of mitotic processes. MZT1 is involved in pathways governing the loss of NLP from mitotic centrosomes, ensuring proper spindle assembly and genomic stability during division. Clinically, mutations and dysregulation of MZT1 are primarily associated with Omodysplasia 1, a rare skeletal dysplasia characterized by short-limbed dwarfism. Additionally, its expression levels have been linked to the progression of lung acinar adenocarcinoma, highlighting its importance in both developmental biology and oncogenesis. |