徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
AHNAK Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611523 |
| 100ul | WGD-Z-2611523 |
详细参数
| 别名 | Neuroblast differentiation-associated protein AHNAK; Desmoyokin |
| 基因名 | AHNAK |
| UniProt ID | Q09666 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 2D4-B2-R6 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 629 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | AHNAK nucleoprotein (AHNAK) is a large structural scaffold protein that plays diverse roles in cellular organization, signal transduction, and membrane repair. It regulates cardiac calcium signaling by interacting with L-type Ca2+ channel beta subunits and the actin cytoskeleton to form subsarcolemmal networks. AHNAK also serves as a scaffold for key signaling enzymes, including phospholipase C-gamma and protein kinase C-alpha, and potentiates TGF-beta signaling through its interaction with Smad3. Beyond its structural functions, AHNAK is involved in blood-brain barrier formation and extracellular vesicle release. Clinically, AHNAK is associated with megacolon and neuroblastoma. It acts as a context-dependent regulator in oncology, functioning as a tumor suppressor through p53 modulation while also contributing to tumor metastasis and the maintenance of cancer stem cell properties. |