徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
SELENBP1 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611543 |
| 100ul | WGD-Z-2611543 |
详细参数
| 别名 | Methanethiol oxidase; MTO; 56 kDa selenium-binding protein; SBP56; SP56; Selenium-binding protein 1 |
| 基因名 | SELENBP1 |
| UniProt ID | Q13228 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2b |
| 克隆号 | 8I4-T9-B9 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 52 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Selenium binding protein 1 (SELENBP1) is a highly conserved cytosolic methanethiol oxidase that plays a central role in sulfur metabolism and redox signaling. It catalyzes the copper-dependent oxidation of methanethiol to formaldehyde, hydrogen sulfide, and hydrogen peroxide. SELENBP1 is widely recognized as a tumor suppressor, with its expression frequently downregulated in various malignancies, including lung, colon, and breast cancers, often through epigenetic silencing. Functionally, it modulates key cellular pathways by interacting with cell-cycle regulators like p21, hypoxia-inducible factor 1-alpha (HIF-1α), and the EED/PRC2 epigenetic complex. These interactions allow SELENBP1 to restrain cell proliferation, invasion, and carcinogenic progression, making its expression level a significant prognostic indicator in oncology. |