徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
TRIM40 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611700 |
| 100ul | WGD-Z-2611700 |
详细参数
| 别名 | E3 ubiquitin ligase TRIM40; Probable E3 NEDD8-protein ligase; RING finger protein 35 |
| 基因名 | TRIM40 |
| UniProt ID | Q6P9F5 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 7G7-C4-J9 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 29 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:200-1:250 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Tripartite motif containing 40 (TRIM40) is an E3 ubiquitin-protein ligase that functions as a critical negative regulator of innate immune responses. It utilizes its tripartite motif domains to mediate the ubiquitination and proteasomal degradation of RIG-I and MDA5 receptors, thereby inhibiting RLR signaling. Additionally, TRIM40 promotes the neddylation of NEMO to stabilize NFKBIA, which effectively blocks NF-kappa-B activation and nuclear translocation. In the gastrointestinal epithelium, TRIM40 serves a protective role by suppressing inflammatory signaling and preventing carcinogenesis. It also interacts with ROCK1 to inhibit the proliferation of colorectal cancer cells via the c-Myc/p21 axis, positioning it as a key modulator of both immune homeostasis and tumor suppression in the gut. |