徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
WDR59 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611705 |
| 100ul | WGD-Z-2611705 |
详细参数
| 别名 | GATOR2 complex protein WDR59; WD repeat-containing protein 59 |
| 基因名 | WDR59 |
| UniProt ID | Q6PJI9 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 6I2-O4-X7 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 109 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:2000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | WD repeat domain 59 (WDR59) is a signaling adaptor protein and an integral component of the GATOR2 complex. It features a characteristic WD40 domain that facilitates protein-protein interactions within the nutrient-sensing machinery of the cell. WDR59 plays a pivotal role in the amino acid-sensing pathway that regulates the activity of the mechanistic target of rapamycin complex 1 (mTORC1). When amino acids are abundant, WDR59 and the GATOR2 complex inhibit the GATOR1 complex, which otherwise acts as a negative regulator of mTORC1. This inhibition allows for the activation of mTORC1 at the lysosomal membrane, promoting cell growth and metabolism. Conversely, amino acid depletion leads to the suppression of this pathway. Clinically, WDR59 has been associated with epilepsy phenotypes, although the exact mechanistic link between its dysfunction and seizure pathogenesis is still under investigation. Its role in fundamental metabolic regulation underscores its importance in maintaining cellular homeostasis. |