徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
HECW1 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611735 |
| 100ul | WGD-Z-2611735 |
详细参数
| 别名 | E3 ubiquitin-protein ligase HECW1; HECT; C2 and WW domain-containing protein 1; HECT-type E3 ubiquitin transferase HECW1; NEDD4-like E3 ubiquitin-protein ligase 1; hNEDL1 |
| 基因名 | HECW1 |
| UniProt ID | Q76N89 |
| 反应种属 | Human |
| 应用 | WB,IP,CHIP |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 9B2-U3-L3 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 179 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:2000; IP-1:100; CHIP-1:100 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 (HECW1) is an E3 ubiquitin ligase that belongs to the NEDD4 family, containing C2, WW, and HECT domains. It is predominantly expressed in the central nervous system and plays a role in protein ubiquitination and degradation. HECW1 regulates various cellular processes, including protein trafficking, RNA metabolism, and autophagy/endolysosomal pathways. It can monoubiquitinate or polyubiquitinate substrate proteins, affecting their stability, localization, and function. HECW1 interacts with proteins involved in neuronal homeostasis and has been implicated in neurodegenerative diseases, particularly familial Amyotrophic Lateral Sclerosis (fALS). It has also been associated with colorectal carcinogenesis and non-small cell lung cancer metastasis. HECW1 expression is upregulated during neuronal differentiation and downregulated with aging, suggesting a protective role in neuronal homeostasis. |