徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
RUFY3 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611736 |
| 100ul | WGD-Z-2611736 |
详细参数
| 别名 | Protein RUFY3; RUN and FYVE domain-containing protein 3; Rap2-interacting protein x; RIPx; Single axon-regulated protein; Singar |
| 基因名 | RUFY3 |
| UniProt ID | Q7L099 |
| 反应种属 | Human |
| 应用 | WB,IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 3J8-Z1-E1 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 52 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | RUN and FYVE domain containing 3 (RUFY3) is a cytosolic adaptor protein that functions as an effector for small GTPases, including Rap2 and ARL8b. In neurons, RUFY3 localizes to growth cones and lipid rafts, where it is essential for establishing neuronal polarity and axon specification by organizing Rap2-dependent actin dynamics. It also acts on endolysosomes by recruiting the JIP4-dynein-dynactin complex to facilitate retrograde lysosome transport and perinuclear positioning. These roles allow RUFY3 to regulate both structural development and organelle distribution. Clinically, RUFY3 overexpression is linked to the progression of gastric cancer. It promotes tumor cell migration and invasion through PAK1-dependent pathways, suggesting a pro-metastatic role in various malignancies. |