徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
GVINP1 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611743 |
| 100ul | WGD-Z-2611743 |
详细参数
| 别名 | Interferon-induced very large GTPase 1; Interferon-induced very large GTPase pseudogene 1 |
| 基因名 | GVINP1 |
| UniProt ID | Q7Z2Y8 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 4Y6-M4-S2 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 279 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | GTPase, very large interferon inducible pseudogene 1 (GVINP1), also functionally identified as GVIN1, encodes a very large, interferon-inducible dynamin-like GTPase. Although historically annotated as a pseudogene, the transcript encodes a cytosolic protein of approximately 209 kDa belonging to the interferon-inducible large GTPase superfamily. Upon stimulation by interferon-gamma, GVIN1 assembles into "coatomer" structures on the surface of cytosolic Gram-negative bacteria, such as Burkholderia thailandensis. In cooperation with other interferon-stimulated genes, it blocks bacterial actin-based motility by displacing actin nucleators, thereby defining an autonomous, cell-intrinsic antimicrobial defense pathway. |