徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
DZIP3 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611769 |
| 100ul | WGD-Z-2611769 |
详细参数
| 别名 | E3 ubiquitin-protein ligase DZIP3; DAZ-interacting protein 3; RING-type E3 ubiquitin transferase DZIP3; RNA-binding ubiquitin ligase of 138 kDa; hRUL138 |
| 基因名 | DZIP3 |
| UniProt ID | Q86Y13 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 3R6-Z6-B8 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 138 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | DAZ interacting zinc finger protein 3 (DZIP3) is an RNA-binding RING-type E3 ubiquitin ligase that plays a significant role in protein homeostasis and gene regulation. It facilitates the polyubiquitination of target proteins by accepting ubiquitin from E2 enzymes, leading to their subsequent proteasomal degradation. Uniquely, DZIP3 also possesses the ability to bind RNA directly, suggesting a dual role in post-translational modification and post-transcriptional control. Primarily localized in the cytoplasm, it participates in innate immunity and MHC class I antigen processing pathways. In clinical research, DZIP3 expression patterns have been utilized for the molecular stratification of gliomas, reflecting its involvement in cancer-related signaling networks. |