徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
CDC20B Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611771 |
| 100ul | WGD-Z-2611771 |
详细参数
| 别名 | Cell division cycle protein 20 homolog B |
| 基因名 | CDC20B |
| UniProt ID | Q86Y33 |
| 反应种属 | Human |
| 应用 | WB,IP,CHIP |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 8N8-U9-Y5 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 57 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:4000; IP-1:100; CHIP-1:100 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Cell division cycle 20B (CDC20B) is a vertebrate-specific regulatory protein that is essential for the initiation of ciliogenesis in multiciliated cells. It localizes to the deuterosome, where it controls the disengagement of centrioles from the deuterosome structure. CDC20B is predicted to function as an activator of the anaphase-promoting complex (APC) and interacts with PLK1 and Separase to promote the release of mature centrioles, a prerequisite for basal body formation. The CDC20B gene also hosts the miR-449 cluster, which coordinates cell cycle exit with multiciliated cell differentiation. Clinically, mutations in CDC20B are associated with primary ciliary dyskinesia (PCD), a motile ciliopathy characterized by impaired mucociliary clearance and chronic respiratory disease, underscoring its fundamental role in the assembly of functional cilia. |