徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
LILRB2 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611810 |
| 100ul | WGD-Z-2611810 |
详细参数
| 别名 | Leukocyte immunoglobulin-like receptor subfamily B member 2; LIR-2; Leukocyte immunoglobulin-like receptor 2; CD85 antigen-like family member D; Immunoglobulin-like transcript 4; ILT-4; Monocyte/macrophage immunoglobulin-like receptor 10; MIR-10; CD antigen CD85d |
| 基因名 | LILRB2 |
| UniProt ID | Q8N423 |
| 反应种属 | Human |
| 应用 | WB,IP,CHIP |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 7B6-V9-X1 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 65 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IP-1:100; CHIP-1:100 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Leukocyte immunoglobulin like receptor B2 (LILRB2) is an inhibitory receptor predominantly expressed on myeloid cells, including monocytes, dendritic cells, and macrophages. It features four extracellular Ig-like domains and a cytoplasmic tail containing immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that recruit phosphatases such as SHP-1 and SHP-2 to dampen immune signaling. LILRB2 binds a broad spectrum of classical and non-classical MHC class I molecules, including HLA-G, to promote immune tolerance. Beyond its role in the immune system, LILRB2 acts as a receptor for beta-amyloid oligomers, contributing to synaptic plasticity impairment in Alzheimer's disease. It is also implicated in the progression of acute myeloid leukemia, where it modulates the tumor microenvironment to favor immune evasion. |