徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
AFAP1L2 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611811 |
| 100ul | WGD-Z-2611811 |
详细参数
| 别名 | Actin filament-associated protein 1-like 2; AFAP1-like protein 2 |
| 基因名 | AFAP1L2 |
| UniProt ID | Q8N4X5 |
| 反应种属 | Human |
| 应用 | WB,IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 6E4-K6-E4 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 91 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Actin filament associated protein 1 like 2 (AFAP1L2), also known as XB130, is a cytosolic adaptor protein that facilitates communication between receptor and non-receptor tyrosine kinases and their downstream signaling pathways. It contains multiple tyrosine phosphorylation sites and proline-rich regions that enable SH2 and SH3 domain binding. AFAP1L2 acts as a protein tyrosine kinase activator, specifically enhancing SRC kinase activity and contributing to SRC-regulated transcription. It is involved in the regulation of gene expression, the mitotic cell cycle, and cytoskeletal signaling. By localizing to lamellipodia and influencing PI3K/Akt signaling, AFAP1L2 plays a significant role in modulating cell proliferation, survival, motility, and invasive potential. |