徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
ARFGAP2 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611814 |
| 100ul | WGD-Z-2611814 |
详细参数
| 别名 | ADP-ribosylation factor GTPase-activating protein 2; ARF GAP 2; GTPase-activating protein ZNF289; Zinc finger protein 289 |
| 基因名 | ARFGAP2 |
| UniProt ID | Q8N6H7 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 1U3-C6-V3 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 56 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | ARF GTPase activating protein 2 (ARFGAP2) is a cytosolic and Golgi-associated protein that functions as a GTPase-activating protein (GAP) for ARF1. By stimulating ARF1 GTP hydrolysis, it regulates COPI-mediated retrograde vesicular trafficking from the Golgi complex to the endoplasmic reticulum. ARFGAP2 is recruited to Golgi membranes via direct interaction with coatomer proteins rather than lipids. While its primary role is in intracellular transport, genetic studies have noted associations between ARFGAP2 and conditions such as combined oxidative phosphorylation deficiency and retinal disease, likely reflecting the downstream consequences of trafficking defects. |