徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
FAM81A Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611837 |
| 100ul | WGD-Z-2611837 |
详细参数
| 别名 | Protein FAM81A |
| 基因名 | FAM81A |
| UniProt ID | Q8TBF8 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 1W1-W7-L3 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 42 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Family with sequence similarity 81 member A (FAM81A) is a brain-enriched postsynaptic scaffold protein localized to the postsynaptic density (PSD) of excitatory glutamatergic synapses. It plays a central role in organizing the PSD by facilitating the assembly of key components, including PSD-95, SynGAP, and NMDA receptors. FAM81A promotes liquid-liquid phase separation, which leads to the formation of membrane-less condensates that enlarge dendritic spines and support neuronal firing. The protein contains an SMC_N-like domain, suggesting potential interactions with nuclear or chromatin-associated proteins, possibly involved in synapse-to-nucleus signaling. While FAM81A is essential for normal neuronal activity and synaptic organization, its specific clinical associations remain under investigation. |