徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
RNF217 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611838 |
| 100ul | WGD-Z-2611838 |
详细参数
| 别名 | E3 ubiquitin-protein ligase RNF217; IBR domain-containing protein 1; Opposite STL; RING finger protein 217 |
| 基因名 | RNF217 |
| UniProt ID | Q8TC41 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 5O8-J2-X9 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 59 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Ring finger protein 217 (RNF217) is a member of the RING1-IBR-RING (RBR) ubiquitin protein ligase family that functions as an E3 ligase to regulate iron homeostasis. It mediates the proteasomal and lysosomal degradation of ferroportin (SLC40A1), the sole cellular iron exporter, particularly in macrophages and enterocytes. This process is modulated by hepcidin signaling and oxidative stress via the NRF2 pathway. RNF217 contains dual RING finger motifs and a transmembrane domain, allowing it to accept ubiquitin from E2 enzymes and transfer it to specific substrates. Additionally, it interacts with the anti-apoptotic protein HAX1, suggesting a role in apoptosis signaling. Dysregulation of RNF217 has been linked to pathological conditions including leukemogenesis and multiple sclerosis. |