徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
SPATA18 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611839 |
| 100ul | WGD-Z-2611839 |
详细参数
| 别名 | Mitochondria-eating protein; Spermatogenesis-associated protein 18 |
| 基因名 | SPATA18 |
| UniProt ID | Q8TC71 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 8N2-B5-I5 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 61 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Spermatogenesis associated 18 (SPATA18) is a p53-inducible protein that serves as a master regulator of mitochondrial quality control. It mediates the degradation of damaged mitochondrial proteins through a process known as MALM (mitochondrial protein catabolic process). SPATA18 promotes the formation of lysosome-like organelles within mitochondria and facilitates the translocation of lysosomal hydrolases to the mitochondrial matrix by interacting with BNIP3 and BNIP3L at the outer mitochondrial membrane. It also binds cardiolipin, potentially forming molecular condensates to manage cardiolipin metabolism. The expression of SPATA18 is directly activated by p53 in response to cellular stress, ensuring the removal of dysfunctional mitochondrial components to maintain cellular integrity. |