徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
CHD6 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611841 |
| 100ul | WGD-Z-2611841 |
详细参数
| 别名 | Chromodomain-helicase-DNA-binding protein 6; CHD-6; ATP-dependent helicase CHD6; Radiation-induced gene B protein |
| 基因名 | CHD6 |
| UniProt ID | Q8TD26 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 8F4-F6-U7 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 305 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:200-1:250 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Chromodomain helicase DNA binding protein 6 (CHD6) is a DNA-dependent ATPase belonging to the SNF2/RAD54 helicase family. It functions as a chromatin remodeler that disrupts nucleosomes in a non-sliding manner to enhance DNA accessibility and regulate gene transcription. CHD6 is ubiquitously expressed in the nucleoplasm, where it colocalizes with RNA polymerase II and responds to DNA damage through poly(ADP-ribose)-dependent recruitment. It plays a significant role in the oxidative stress response by interacting with NFE2L2 to activate antioxidant genes, thereby promoting cell survival. Additionally, CHD6 can repress viral replication, such as that of the influenza virus, by localizing to inactive chromatin. Its ability to modulate chromatin architecture makes it a key regulator of the cellular response to genomic instability. |