徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
GIPC2 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611848 |
| 100ul | WGD-Z-2611848 |
详细参数
| 别名 | PDZ domain-containing protein GIPC2 |
| 基因名 | GIPC2 |
| UniProt ID | Q8TF65 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2b |
| 克隆号 | 4Q4-U8-J6 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 34 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | GIPC PDZ domain containing family member 2 (GIPC2) is a PDZ domain-containing protein that facilitates protein-protein interactions and is localized to extracellular exosomes. It is primarily expressed in the ascending colon and kidney, where it functions as an endocrine-specific tumor suppressor. GIPC2 interacts with Fzd7 to modulate WNT signaling pathways, which can influence cellular proliferation and metastasis. It is a paralog of GIPC1 and is involved in maintaining cellular polarity and trafficking. Clinically, GIPC2 is associated with Waardenburg syndrome type 4A, a condition characterized by sensorineural hearing loss and pigmentary abnormalities resulting from defects in melanocyte and enteric neuron development. It is also linked to pheochromocytoma, a catecholamine-secreting tumor of the adrenal glands that leads to severe hypertension and other metabolic disturbances. |