徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
DLG3 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611873 |
| 100ul | WGD-Z-2611873 |
详细参数
| 别名 | Disks large homolog 3; Neuroendocrine-DLG; Synapse-associated protein 102; SAP-102; SAP102; XLMR |
| 基因名 | DLG3 |
| UniProt ID | Q92796 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 5B8-C2-G1 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 90 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:50 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Discs large MAGUK scaffold protein 3 (DLG3) is a membrane-associated guanylate kinase (MAGUK) family protein that serves as a critical scaffold at excitatory synapses. It orchestrates the localization and stabilization of glutamate receptors, particularly NMDA receptors, through its multiple PDZ domains. DLG3 interacts with key synaptic proteins, including NETO1, GRIN2B, and SYNGAP1, while its guanylate kinase-like domain binds to DLGAP proteins to maintain postsynaptic architecture. These interactions are essential for synaptic plasticity and learning following NMDA receptor signaling. Additionally, DLG3 negatively regulates cell proliferation by interacting with the adenomatosis polyposis coli (APC) tumor suppressor protein. Clinically, mutations in the X-linked DLG3 gene are well-established causes of X-linked intellectual disability and intellectual developmental disorder 90, highlighting its fundamental importance in neurodevelopment and neuronal function. |