徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
BCL2L2 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611875 |
| 100ul | WGD-Z-2611875 |
详细参数
| 别名 | Bcl-2-like protein 2; Bcl2-L-2; Apoptosis regulator Bcl-W |
| 基因名 | BCL2L2 |
| UniProt ID | Q92843 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 8M4-G1-N6 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 20 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:250-1:500 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | BCL2 like 2 (BCL2L2) is an anti-apoptotic member of the BCL-2 family that promotes cell survival by sequestering pro-apoptotic BH3-only proteins, thereby preventing mitochondrial outer membrane permeabilization and subsequent caspase activation. It is prominently expressed in the nervous system and testis, where it supports the survival of neurotrophin-dependent neurons and postmitotic Sertoli cells. BCL2L2 interacts with survival pathways such as NF-kappaB and TNFR1 signaling to block BAX-mediated apoptosis. Clinically, dysregulation of BCL2L2 is associated with cancer cell survival and therapeutic resistance. It is also linked to glioma susceptibility and oculopharyngeal muscular dystrophy, making it a significant target for the development of pro-apoptotic cancer therapies. |