徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
ARHGEF2 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611878 |
| 100ul | WGD-Z-2611878 |
详细参数
| 别名 | Rho guanine nucleotide exchange factor 2; Guanine nucleotide exchange factor H1; GEF-H1; Microtubule-regulated Rho-GEF; Proliferating cell nucleolar antigen p40 |
| 基因名 | GEF-H1 |
| UniProt ID | Q92974 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 5D7-L1-Z4 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 111 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1) is a microtubule-associated factor that activates Rho family GTPases, primarily RhoA, by catalyzing GDP-GTP exchange. It is typically sequestered in an inactive state on microtubules and becomes activated upon microtubule depolymerization, thereby coupling microtubule dynamics to actin cytoskeleton remodeling and cell migration. GEF-H1 is involved in regulating cytokinesis, epithelial barrier function, and mechanotransduction. Pathologically, GEF-H1 is transcriptionally upregulated by oncogenic Ras/Raf/MEK/ERK signaling, supporting transformed growth in Ras-driven tumorigenesis. It also contributes to TNF-alpha-mediated barrier dysfunction and wound healing. In immune contexts, GEF-H1 modulates antigen presentation and tight-junction permeability, linking cytoskeletal regulation to inflammatory responses and barrier integrity. |