徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
FXYD5 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611891 |
| 100ul | WGD-Z-2611891 |
详细参数
| 别名 | FXYD domain-containing ion transport regulator 5; Dysadherin |
| 基因名 | FXYD5 |
| UniProt ID | Q96DB9 |
| 反应种属 | Human |
| 应用 | IHC-P,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 8M9-O6-Q1 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 19 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:250-1:500; ELISA-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | FXYD domain-containing ion transport regulator 5 (FXYD5), also known as dysadherin, is a single-span type I membrane protein that plays a significant role in regulating ion transport by interacting with the Na+/K+-ATPase. It features a unique structure with a large extracellular domain exceeding 140 amino acids and a short intracellular C-terminal segment, which is critical for its localization and function. FXYD5 modulates cellular junctions, influences cell adhesion, and impacts chemokine production, thereby affecting various physiological processes. Importantly, FXYD5 is often overexpressed in several cancers, including breast and ovarian cancers, where it correlates with tumor progression and metastasis. Its upregulation has been associated with poor prognosis and shorter survival rates in patients with high-grade serous ovarian carcinoma (HGSOC). |