徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
SENP8 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611913 |
| 100ul | WGD-Z-2611913 |
详细参数
| 别名 | Sentrin-specific protease 8; Deneddylase-1; NEDD8-specific protease 1; Protease; cysteine 2; Sentrin/SUMO-specific protease SENP8 |
| 基因名 | SENP8 |
| UniProt ID | Q96LD8 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 5M3-Z3-Y9 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 24 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:200-1:250 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | SUMO peptidase family member, NEDD8 specific (SENP8) is a cysteine protease that plays a central role in the NEDD8 conjugation pathway. It is responsible for processing precursor NEDD8 into its mature form and deconjugating NEDD8 from targets such as cullins and Ubc12. By preventing aberrant hyper-neddylation, SENP8 ensures the proper activation of cullin-RING ligases, which are essential for proteostasis and G1/S cell cycle progression. In the nervous system, it regulates actin dynamics and Wnt/beta-catenin signaling to support neurite outgrowth and synapse maturation. Clinically, SENP8 deficiency is associated with impaired cell growth and neurodevelopmental deficits. It is also linked to the host response in rare viral encephalitides, such as Kunjin encephalitis and Kyasanur Forest Disease. |