徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
FBXO34 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2612066 |
| 100ul | WGD-Z-2612066 |
详细参数
| 别名 | F-box only protein 34 |
| 基因名 | FBXO34 |
| UniProt ID | Q9NWN3 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2b |
| 克隆号 | 6G8-A3-F8 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 78 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | F-box protein 34 (FBXO34) is a substrate-recognition subunit of the SCF (SKP1-CUL1-F-box) E3 ubiquitin ligase complex. It utilizes its F-box domain to interact with SKP1, facilitating the recruitment of specific target proteins for ubiquitination and subsequent proteasomal degradation. FBXO34 is involved in several diverse biological processes, including the post-transcriptional modulation of latent HIV-1 activation and the regulation of oocyte maturation. While many of its specific substrates remain to be fully characterized, the protein is known to play a role in viral latency and cellular development. It is located on human chromosome 14 and contains various protein-protein interaction domains that allow it to function within the broader ubiquitin-proteasome system. Its activity is considered context-dependent, contributing to the fine-tuning of protein levels necessary for maintaining cellular homeostasis. |