徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
CRNN Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2612097 |
| 100ul | WGD-Z-2612097 |
详细参数
| 别名 | Cornulin; 53 kDa putative calcium-binding protein; 53 kDa squamous epithelial-induced stress protein; 58 kDa heat shock protein; Squamous epithelial heat shock protein 53; Tumor-related protein |
| 基因名 | CRNN |
| UniProt ID | Q9UBG3 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 7W2-D3-H4 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 53 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Cornulin (CRNN) is a 495-amino acid, squamous epithelial tissue-specific protein encoded by the CRNN gene located at chromosome 1q21.3, within the epidermal differentiation complex region. Structurally, Cornulin belongs to the "fused gene" family and contains two EF-hand calcium-binding domains at its N-terminus and two glutamine- and threonine-rich 60-amino acid repeats at its C-terminus, features that are important for its role in calcium signaling and epidermal differentiation. Cornulin is involved in the mucosal and epithelial immune response, acts as a survival factor for squamous epithelial cells, and helps regulate cell proliferation by inducing G1 cell cycle arrest. Disease associations include its downregulation in eczema and upregulation in psoriasis, as well as links to esophageal cancer and squamous cell carcinoma, where altered Cornulin expression correlates with enhanced metastasis and poorer survival outcomes. |