Overview
| 别名 | Small glutamine-rich tetratricopeptide repeat-containing protein alpha; Alpha-SGT; Vpu-binding protein; UBP |
| 基因名 | SGTA |
| UniProt ID | O43765 |
| 反应种属 | Human |
| 应用 | WB,IP,CHIP |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 1E7-R1-M7 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 34 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IP-1:100; CHIP-1:100 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Small glutamine rich tetratricopeptide repeat co-chaperone alpha (SGTA) is a ubiquitously expressed co-chaperone that plays a central role in cytosolic protein quality control. It is characterized by an N-terminal dimerization domain and a central array of three tetratricopeptide repeat (TPR) motifs that form a binding groove for hydrophobic or misfolded client proteins. In coordination with the BAG6/UBL4A/GET4 complex and HSP70 family chaperones, SGTA facilitates the proper targeting of these clients to the endoplasmic reticulum or their diversion to degradation pathways. Beyond its role in proteostasis, SGTA modulates steroid and growth hormone receptor signaling and participates in diverse cellular processes, including cell division, apoptosis, and intracellular trafficking. |
检测原理